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When NF-kB interacts with IkB in the cytoplasm, it is unable to enter the nucleus and bind to the promotor region of proinflammatory genes

Accessed 10 Aug 2025 Wang Y, Li P, Kong L (2013) Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery

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This vicious cycle perpetuates epigenetic deregulation via histone and DNA hypermethylation (136), and drives the progression of diverse cancers, including glioma, glioblastoma, acute myeloid leukemia (AML), intrahepatic cholangiocarcinoma, melanoma, angioimmunoblastic T-cell lymphoma (AITL), chondrosarcoma, sporadically in melanoma, medulloblastoma, astrocytomas, hepatocellular, oligodendrogliomas, oligoastrocytomas, squamous cell carcinoma, colon carcinoma, nasopharyngeal carcinoma, sarcoma, stromal tumors, cervical cancer, gastric cancer, renal carcinoma, lung cancer, ovarian cancer, thyroid cancer, breast cancer, and pancreatic cancer (57, 61, 62) ( Figure 7 )