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doi: 10.1042/0264-6021:3610417

Lipoic acid also protected liver from oxidative stress-induced liver injury in methotrexate-treated rats through the activation of Nrf-2 pathway and other anti-inflammatory pathways (37)

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It has also been shown to accelerate fat oxidation and decrease fat production in the body ( However, the effectiveness and safety of garcinia cambogia and HCA for weight loss have been called into question, as more recent studies have revealed that these supplements may not be as powerful as earlier research suggested ( summary Garcinia cambogia contains an organic acid called HCA, which may promote weight loss by suppressing appetite and enhancing fat oxidation

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The successful application of metabolic inhibitors will lie in accurate metabolic phenotyping and stratification of tumors to predict which respond to the given drugs