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Is it SIBO or SIFO

Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues

& Nuttbrock, L

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4.3Role of portal hypertension in intestinal permeability While there are similarities in the molecular events in IBD and chronic liver diseases, portal hypertension is a typical feature of decompensated liver cirrhosis and a main driver of the systemic inflammation associated with liver cirrhosis, and it can occur in IBD [98]

Hamet P, Tremblay J