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peripheral vascular thrombosis Hematological: Polycythemia vera (a rare type of blood cancer) Gastrointestinal: Mild, transient diarrhea Dermatological: Itching

benefits are generally greatest when B12 or other nutrient status is genuinely low

Table 2)

It's important to remember that individual responses differ, and factors like overall health, diet, and the severity of any B12 deficiency can influence how quickly changes become noticeable

Schneck K, Urva S

Some factors associated with low intrinsic factor include: Being over 60 Northern European or Scandinavian ancestry A family history of intrinsic factor issues Autoimmune conditions such as Type 1 diabetes Surgeries where part of the stomach has been removed Other factors that may affect intrinsic factor or overall B12 absorption include: Stomach lining inflammation Conditions affecting the small intestine Long-term use of antacids Disruption of gut flora Certain gastrointestinal infections If any of the above apply, holding B12 sublingually for 30 seconds before swallowing may be helpful