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The earliest models were those of constitutive multiple tumor suppressor 1 (p16) and cyclin-dependent kinase inhibitor 1A (p21) knockout and overexpression, which were used to study the pathophysiological effects of singular senescence regulators in vivo

Chang et al ., 2007)

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Furthermore, urothelium from individuals with IC has demonstrated reduced cell proliferation and increased cell permeability (Fiehn and Kim, 2014)

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sGCs are important for both vascular and cardiac function, however, in patients with heart failure, sGCs are not fully activated, resulting in abnormal myocardial and vascular function