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Mitochondrial damage may be caused by exposure to toxic substances such as heavy metals (mercury, lead), toxins, and air pollution

The Th1/Th2 imbalance in ME/CFS drives broader immune dysregulation, including overreaction to pathogens and mismanagement of immune responses against host tissues, potentially contributing to the autoimmune features of ME/CFS

(13) evaluated carnitine levels in children with or without ketogenic diet

The onset of metabolic inflexibility has been associated with micronutrient deficiencies and nutrient overload as well as the inevitable aging process

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Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle