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Assessments of fatigue were performed by all patients at the first time point during the period of standard HD, and within 2 weeks before commencement of EHD system (M0) using questionnaire asking How did you feel tired in the previous HD day, and the next day of HD? And NRS (HD and HD-free days) were repeatedly asked at the 1st month (M1), 3rd months (M3), 6th months (M6), and 12th months (M12) after commencement of E-HD system

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