glutathione peroxidase deficiency 4: a new player in neurodegeneration? The glutathione peroxidase family: Discoveries

Lckenlose Nachsorge regelmssige Check-ups, digitale Follow-ups und schnelle Anpassung deines Plans bei Bedarf

While the immediate consequence of amplification of mitochondrial oxidant stress is loss of mitochondrial protein function due to modification of thiols [33], peroxynitrite mediated nitrotyrosine formation [48] and oxidative mitochondrial DNA damage [41], the critical event resulting in escalation of cell wide damage is induction of the mitochondrial permeability transition (MPT)

J Biol Chem 279:1624616253

Transcriptional and post-transcriptional regulation of both subunits has been described

Comparison among mammalian GPxs 14 As discussed above, the active sites of the mammalian GPxs 14 are highly conserved

It mainly occurs between the 3rd and 4th toes