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Theoretically, inactivation of GPx-1 by MeHg involves a direct interaction of mercury with the selenol of GPx-1

Future studies must better define the molecular context of antioxidant action, including the following: which biomolecules are being protected, the specific radical species targeted, the tissue and subcellular distribution of the antioxidant, and how levels of endogenous antioxidants and reactive oxygen species (ROS) change post-administration (e.g., within the mitochondria)

Frey GE, Durmus T, Sills EO, Isik F, Comer MM

Irimajiri K

It can also occur in young athletes or children who become so engrossed in play that they forget to drink water

doi: 10.3390/nu10050580 18