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ERRs are transcriptional regulators involved in cellular energy metabolism, mitochondrial function, oxidative phosphorylation, and fatty-acid utilization

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(7) The hepatic microsomal cytochrome P450 (CYP) system metabolizes most drugs to non-toxic products, but occasionally to toxic metabolites and/or reactive oxygen species (ROS), a process called microsomal (oxidative) stress

All these results, although preliminary, encourage carrying out larger randomized controlled clinical trials

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