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This interconnectivity means that chronic pain in comorbid conditions is often multimechanistic, involving concurrent elements of nociceptive (e.g., joint damage in obesity), neuropathic (e.g., nerve compression in cancer, metabolic injury in diabetes), and nociplastic (e.g., central sensitization fueled by systemic inflammation) pain

J Thorac Cardiovasc Surg (2003) 125:57891

Bronstein, J., Tawdekar, S., Liu, Y., Pawelczak, M., David, R., & Shah, B

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Mfat-1 ameliorates cachexia after hypoxic-ischemic brain damage in mice by protecting the hypothalamus-pituitary-adrenal axis

Peer review Peer review information Nature Protocols thanks Jong Bum Lee, Veikko Linko, Chengde Mao, Simona Ranallo and Olavi Reinsalu for their contribution to the peer review of this work