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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

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Lau Siu-Yee, Dermatology Director of Shu Tin Clinic and Medical Director of Wah Yan Aesthetic Center, their primary differences are in peptide chain structure and target activity

Despite widespread anecdotal reports of effectiveness, robust clinical data in humans is lacking, with most research being conducted in animal models 6 7