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Imbalances in T cell subpopulations, including reductions in regulatory T cells, have been identified as sources of inflammatory cytokines and responses, alongside abnormal cytokine levels 13,14

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10.1053/j.ajkd.2014.02.020 46 ItoS.HiguchiY.YagiY.NishijimaF.YamatoH.IshiiH.et al (2013)

coli bacteria are a normal component of the gut microbiota, certain strains can grow rapidly in inflammatory environments and produce alpha-hemolysin, a toxin that may cause inflammation, bleeding, and leaky gut [7, 31]