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Consistent with this general mechanism, oxidative stress is a major proposed pathogenic mechanism for neurodegenerative disorders in which mitochondrial defects have been reported, including Parkinsons, Huntingtons, and Alzheimers diseases

Deboever N, Eisenberg MA, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC , Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Rajaram R

doi: 10.1016/j.rbmo.2022.05.010 129 WangLTangJWangLTanFSongHZhouJet al

As indicated above kynureninase, which is encoded by the KNYU gene, is also used for the conversion of kynurenine to anthranilic acid with the release of alanine

There is controversy surrounding the bodys ability to absorb glutathione in the intestinal tract

Melatonin prevents metal oxidation by neutralizing free radicals produced in redox reactions, such as the Fenton reaction and the HaberWeiss reaction (HWR), or by chelating metal ions [70]