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It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling

Their results clearly show the role of glycemic control and the route of insulin administration in the normalization of IGF-1, IGFBP-1, and GH in patients with recent-onset T1DM

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