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Clinical investigations have shown that melatonin concentrations in the CSF of patients with AD are several-fold lower than those in age-matched control subjects without AD [75, 229]

Agents can bind and couple with MRGPRX2, which stimulates phosphorylation cascades, augments intracellular calcium levels, and induces degranulation of mast cells

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In cell culture experiments, it exhibits similar effects to SAHA, as it has the capability to impede cancer cell growth and induce both DNA double-strand break damage and cell apoptosis simultaneously (Pojani and Barlocco, 2021)
