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Of importance, imaging studies on human cancer survivors reveal a reduction in several white matter tracts, suggesting reduced myelination (Deprez et al., 2011

256 Mitochondrial complex III produces ROS immediately after stimulation, which has an essential role in inflammatory macrophage activation
(13, 14) found that TFPs promoted apoptosis of B16 melanoma cells by inducing G2/M cell cycle arrest, and activating lipid transport and metabolism

In summary, the implication of IGF-1 in glucose and lipid metabolism and its derangements when the GH/insulin/IGF-1 axis balance fails is well documented

References Strobl JS, Thomas MJ
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