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Similar content being viewed by others Introduction The liver is the largest endocrine organ in the body and is critical for maintaining homeostasis, serving as the primary site of xenobiotic metabolism, production of coagulation factors, and removal of ammonia as well as a multitude of other essential functions 1

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doi: 10.1016/j.wneu.2012.11.062

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It has poor metabolic stability, a short half-life in circulation, and limited bioavailability when administered systemically