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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

Abu-Zaid A, Bukhari IA, Alyousef A, Baradwan S, Bin Muaythir N, Almudaymigh Y et al (2023) Effect of selenium supplementation on cardiometabolic risk factors in polycystic ovary syndrome (PCOS) patients: A systematic review and meta-analysis of randomized clinical trials

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Always start at a lower dose and increase gradually under medical guidance

For example, the influx of Na + and the efflux of K + are regulated by abluminal Na-K-ATPase against the concentration gradient for maintenance of the electrochemical gradient across the cell membrane
