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These include dietary calcium, ethanol, and caffeine

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It can also cause several GI side effects, which may indirectly affect weight loss 9

64 , 65 In murine MM models, inhibiting HIF1 downregulated proangiogenic genes, including vascular endothelial growth factor, and led to a reduction in the weight and volume of the tumor burden

They can be helpful in the right situation, but they work best when we use them thoughtfully and in context