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Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor

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Titration protocols therefore hold a dose until nausea and other gastrointestinal effects settle rather than escalating on a fixed target date

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Amphotericin B nephrotoxicity can be classified by two mechanisms: 1) the effects of amphotericin B on renal blood flow and glomerular filtration, and 2) the direct toxic effects of amphotericin B on (primarily) the distal tubules