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Furthermore, it has been shown in other studies that the protective effects against cerebral ischemia-reperfusion injury, achieved by inhibiting ferroptosis, are partially diminished upon induction by RSL3 (125,132)

Published December 29, 2022

Research Square Print

doi:10.1080/01635581.2019.1637005

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Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results