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Personal Preference for Maintenance: Once acute deficiency symptoms are managed, some patients may prefer to switch to oral supplements for ongoing maintenance, again, strictly under medical supervision to ensure their levels remain stable

o Martin Lange emphasized this point, noting that semaglutide's 26% CV risk reduction in diabetes stands out numerically against competitors' 12%, countering the notion that all GLP-1s provide the same CV benefit Enhancing the Patient Value Proposition: Beyond clinical endpoints, Novo Nordisk is highlighting Wegovy's impact on quality of life

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Clinical trials would need to assess both hemodynamic parameters and clinical outcomes including walking distance, pain scores, and amputation rates to establish therapeutic benefit