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However, while there is evidence to support the role of vitamin E supplementation in preventing neurodegeneration by scavenging excess free radicals, many research studies have yet to confirm these findings, some with contradictory results, and the exact role of vitamin E in the remains hotly debated

In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]

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Dev Cell (2022) 57:17281741.e6

Molecules 27(5):1750 Ngo V, Duennwald ML (2022) Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease

To test our hypothesis, we deleted genes coding for the periplasmic binding protein OppA or the permease OppC in cells lacking glutathione biosynthesis, creating double mutants gshA oppA and gshA oppC (see Figure 5A for a schematic overview)