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Substance abuse definitions have evolved over time, but key features include relapse to drug use even after prolonged abstinence, escalation of drug intake, tolerance to the effects of drugs, craving, and continued use despite adverse consequences to health, financial status and relationships (American Psychiatric Association, 2013

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(2018) The biologic effect of hydrogen sulfide and its function in various diseases

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Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H, Hashimoto SI, Matsushima K (2002) Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system

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