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In addition, IFNG stimulates ACSL4 expression through an IRF1 (interferon regulatory factor 1)-dependent mechanism, thereby augmenting arachidonic acid-related ferroptosis in animal models and impeding tumor growth [187] (Fig

Higher temperature also increases the efficiency of the Fenton-type reaction ( OH generation from H 2 O 2 , which is highly abundant in mitochondria) 290

This process involves the cytosolic enzyme serine hydroxymethyltransferase (SHMT1), which catalyzes the conversion of serine to glycine and transfers a one-carbon unit to THF to form 5,10-methylenetetrahydrofolate

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