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It is recognized as a natural anti-inflammatory agent with a broad spectrum of medicinal effects, including anti-inflammatory, antimicrobial, antioxidant, immune-modulatory, anti-cardiovascular, and hepatocyte-protective activities (Ghavidel et al., 2023

COVID-19 can cause systemic inflammation and oxidative stress, which may impact mitochondrial function

For instance, ibuprofen has been shown to downregulate inducible nitric oxide synthase (iNOS) and reduce NO release during inflammation, thereby indirectly influencing nociceptive signaling [93,94,95]

Therefore, both pharmaceutical and nutraceutical industries are encouraged to incorporate genome-based formulations into ongoing research

[DOI] [PubMed] [Google Scholar] 60.Gonzlez-Foruria I, Santulli P, Chouzenoux S, et al

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