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Once inside the mitochondria, these fatty acids undergo beta-oxidation, a metabolic pathway that breaks them down into acetyl-CoA, which then enters the Krebs cycle to generate adenosine triphosphate (ATP), the bodys main energy currency

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Authors contributions YNN drafted the manuscript

Although spatial multiomics and single-cell omics techniques can provide a deeper understanding of tissue and cellular heterogeneity, elucidation of the molecular and phenotypic heterogeneity in disease pathways underlying diabetic complications and the complex interplay of risk factors, such as obesity, aging, and inflammation, poses significant challenges to the discovery of biomarkers and the development of standardized therapeutic strategies

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