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If you are self-supplementing with high doses, discuss this with your GP to ensure it is appropriate and safe for your individual circumstances

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NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
Enteric coatings could protect peptides from gastric acid but did not address enzymatic degradation or poor absorption in the small intestine

Y.Yokota-HashimotoH.TaguchiR.et al (2014)
