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Chaperones attempt to remedy the unfolded protein first and, if unsuccessful, activate cellular programs, including the UPR, heat shock response (HSR), and ER-associated degradation (ERAD), to induce processes to either fix the problem or destroy the unfolded proteins (324, 325)

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10.1161/01.str.0000206281.77178.ac Stroke 361 YolkenR

233 In one large observational study that followed nearly 500,000 participants for about 11 years, drinking up to 34 cups per day of any type of coffee, including decaffeinated, instant, or ground coffee, was associated with lower risks of all types of chronic liver disease, including NAFLD, as well as cirrhosis and hepatocellular cancer