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S., Al-Fudhaili, R

Many anticonvulsant drugs act by increasing GABA in the synapse.[ref] Genetic variants that decrease the function of the GABA-A receptors essentially decreasing GABA inhibition are linked to an increased risk of epileptic seizures.[ref] Insomnia: Brain GABA levels were studied in people with primary insomnia who were not on medication

RB&E 23 (1), 49

In parallel, high lactate concentrations promote the differentiation of Tregs and myeloid-derived suppressor cells (MDSCs), further dampening anti-tumor immunity (152)

On the other hand, using a FRET lactate sensor, the group demonstrated that depolarization, via depletion of the astrocytic lactate reservoir in cultured astrocytes, may occur via a non-identified anion channel (Sotelo-Hitschfeld et al., 2015)

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