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Knockdown of NNMT elicits heightened energy expenditure in adipose and hepatic tissues, mitigates lipid accumulation, and enhances insulin sensitivity
doi: 10.1016/j.freeradbiomed.2020.07.037
None of the metabolites are pharmacologically active [5,6]
doi: 10.1152/ajprenal.00614.2014 186
A nonexclusive alternative explanation for the kinetic patterns with HEDS (and the decreased enzyme activity at high GSH concentrations) could be a Grx(SSCH 2 CH 2 OH) intermediate that is attacked by GSH according to monothiol mechanism (i) from Fig
doi: 10.1096/fj.202401119R 26
