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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

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The RNA purification, reverse transcription, library construction, and sequencing were performed at Shanghai Biotechnology Corporation Co., Ltd

C.KumarM.PulidoC.TkachukA

In association with the expected formation of a 13( S )-hydroperoxide, intramolecular nucleophilic substitution (S Ni ) between the hydroperoxy (nucleophile) and 15(16)-epoxy group (electrophile) forms a 13( S ),(15( S ))-epidioxy-16( S )-HODE (Scheme 20)