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In addition, compartmental or PBPK-based modeling may improve the interpretation of nanocarrier distribution, particularly for systems with formulation-dependent or nonlinear pharmacokinetics (Yuan et al., 2019

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During adulthood, serum B12 concentrations tend to decline with age, especially in the elderly (Wahlin et al., 2002), probably arising from the gradual decrease in both gastric acidity and intrinsic factor production that occurs with aging (Asselt et al., 1998

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In some embodiments, the formulation or composition has a viscosity of about 150 cP

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