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Metalorganic complexes (MOCs) or metalorganic frameworks (MOFs) possess a great deal of attraction in nanodrug delivery systems for tumors

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30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)

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Additionally, hIDO1 has a broad substrate specificity, catalyzing the oxygenation of a variety of indoleamines such as 5-hydroxytryptophan, 1-methyltryptophan, 5-methyltryptophan and 5-fluorotryptophan [135] and even serotonin in other organisms [136]