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Although researchers are still investigating the exact mechanism, most evidence suggests that metformin interferes with the absorption of vitamin B12 in the last part of the small intestine, known as the ileum

This is one of the important actions regarding wound healing

Pneumonia (Nathan Qld.) , 13 (1), 7

If the vitamin B12 levels normalize, oral replacement may continue

Valenciano et al., 2012)

This is probably explained by the fact that S-adenosylmethionine (SAM), which is important for many epigenetic processes, is regenerated by methylcobalamin, whereas cyanocobalamin reduces it (as we explored above)
