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Such observations are consistent with earlier studies by Pischetsrieder et al

Hyper-stimulation of low-grade inflammatory mediators triggers peripheral endotoxemia and a persistent inflammatory state, popularly called inflammaging (reviewed in Mechanistic Insight Into Gut Microbiome-Mediated Neurodegeneration A clear pathophysiological link between immune and metabolic dysregulation and neurodegenerative disorders in the brain had been previously established (reviewed in Yan et al., 2020)

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All cells were cultured in 37 C with 5% CO 2

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