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Many patients start to feel improvements within a couple of days, while others may take longer to notice changes

Some physicians limit B12 shots only to those with documented deficiencies or absorption issues to prevent unnecessary treatment where dietary B12 is sufficient

Initially, shots might be administered weekly to kickstart metabolism and energy levels, particularly if there is a noticeable deficiency or if the person needs an immediate boost in their weight loss efforts

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At 12 weeks follow-up, both groups 1 ( n = 83) and 2 ( n = 88) demonstrated a significantly greater reduction in pain relative to placebo ( n = 85)

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