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Compared with adults, very low exposure to glucuronide but higher exposure to sulfate, cysteine, and mercapturate metabolites was found, of which the relevance is not yet known

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doi: 10.1016/j.phrs.2020.105299 98 GaliaACalogeroAECondorelliRFraggettaFCorteALRidolfoFet al

5A, as concentrations of RSL3 higher than 1 M further induced cell death), and under these conditions, IRE1 deficiency would increase cystine uptake and GSH level through SLC7A11 and GCLC upregulation, mitigating the effects of GPX4 inhibition by RSL3