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reported a marked decrease in the activities of complex I, II, and III of the respiratory chain in oligodendrocyte cultures treated with cuprizone and in mitochondria isolated from cuprizone-treated mice confirming that cuprizone disturbs mitochondrial function and thus compromises the energy metabolism of cells (Pasquini et al., 2007)
10.1016/j.cub.2018.01.004 Curr
But as research evolves, our team has found that the narrative is far more nuanced
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