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Initial post-treatment discomfort is generally mild, similar to the feeling after a hard work out, and is easily controlled with oral medication, usually Tylenol, but a narcotic can be used if needed

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This happens when the alpha-melanocyte-stimulating hormone binds to melanocortin receptors, triggering melanin production in skin cells

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Drug-induced mucocutaneous pigmentation: Diffuse pigmentation may be associated with systemic intake of drugs