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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

Patients on selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants need closer monitoring if phentermine is used, as serotonin syndrome, though rare, is a medical emergency

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But the weight gain is not a direct result of the deficiency but rather an indirect result

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Water, for injections, excipient (+)