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The ER-NLRP6 axis interacts with key autophagy-related proteins (ULK1, BECN1, LC3B, ATG16L1, p62), regulating autophagosome biogenesis and autophagic flux

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[DOI] [PubMed] [Google Scholar] 192.Lorant T, Wilton J, Olausson M, Tufveson G, Johnsson C

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High ROS levels cause a sustained activation of NF-B and of FoxO which then activate two muscle-specific E3 ubiquitin ligases, atrogin-1 or muscle atrophy F-box (MAFbx) and muscle RING (Really Interesting New Gene)-finger protein 1 (MuRF-1) [52]