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Olshansky, S

Structure guided mutagenesis and homolog screening reveals hinT mutants with increased affinity HinT is highly conserved from bacteria to humans, including the hydrophobic and polar residues which form the adenine and phosphate binding pockets 28 .In contrast, the C terminus of hinT is highly variable among homologs and contributes to substrate specificity and catalytic function in vitro 34,37

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doi: 10.1146/annurev.med.53.082901.104018

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