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In addition, other administration routes such as nasal, transdermal, vaginal, and rectal are investigated to potentially enhance therapeutic effects and maximize clinical efficacy of probiotics beyond oral delivery (218)
Carnitine may be involved because its concentration in tissues declines with age, which deteriorates the mitochondrial membrane
doi: 10.1038/nature05915
Goodman, B
Further exploration of ATRX-related pathways may provide novel treatment strategies for ATRX-mutated GBMs, particularly through targeted approaches that disrupt ALT and DNA repair mechanisms
Raun, B
