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168 SimonneauC.LeclercqB.MougelA.AdriaenssensE.PaquetC.RaibautL.et al (2015)

doi: 10.1093/ajcn/87.5.1128

This cascade might stimulate the synthesis and secretion of growth hormone (hGH) from somatotrophs in the pituitary gland

Additionally, evidence suggests that metal deficiency destabilizes the SOD1 protein and structural distortion of apo-SOD1 results in its aberrant oligomerization (Strange et al., 2007

10.3389/fnins.2022.792970 191 MaekA.StrzemskiM.KurzepaJ.KurzepaJ

The pathophysiology of advanced-stage lipedema remains poorly defined, and no validated biomarkers or targeted therapies are currently available
