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Jamilian H, Jamilian M, Samimi M, Afshar Ebrahimi F, Rahimi M, Bahmani F, Aghababayan S, Kouhi M, Shahabbaspour S, Asemi Z (2017) Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

In addition to being activated by IP 3 binding, the IP 3 R channel function is regulated by Ca 2+ ion at various concentrations

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Nat Med (2020) 26(5):6817

So, while it's important to note the rise in TMAO associated with high doses, carnitine supplementation may also offer cardioprotective properties for people with certain conditions