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Second hit: Stimuli such as trauma or hypothermia cause crystal shedding

Samy , Juan Sanabria , Francesco Sanmarchi , Itamar S

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176 Proc Natl Acad Sci USA 1998 95 : 37923797 Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M

3I, J, weakening NOX1 expression increased GSH and decreased MDA levels

Additionally, gagunin D, a highly oxygenated diterpenoid from the marine sponge Phorbas sp., was also found to exhibit anti-melanogenic properties by downregulating the expression of proteins associated with melanosome transfer, including Rab27A, MLPH and myosin Va (133)
