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doi: 10.1159/000524400

Table 1 Animal studies evaluating the anti-inflammatory effect of GLP-1 in atherosclerosis

Similarly, both in vivo feeding with a choline-rich diet and in vitro trimethylamine-N-oxidase (TMAO) stimulation increased TMAO-dependent NLRP3 inflammasome activation and expression of IL-1, IL6, TNF-, CXCL9, and CXCL10, supporting that NLRP3 is a key proteolytic activator in the macrophage response to a high choline and TMAO production ( Figure 3 )

To observe in vivo long-term biocompatibility, the body weights of the mice were measured every other day for one month after intravenous injection of GSH-CDs (5 mg kg 1 ) or PBS
