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2016;152:R23R30

Folic acid is essential for cell growth and tissue repair, particularly in pregnant women or those with anemia

McLaughlin LA, Niazi U, Bibby J, David JP, Vontas J, Hemingway J, Ranson H, Sutcliffe MJ, Paine MJ: Characterization of inhibitors and substrates ofAnopheles gambiaeCYP6Z2.Insect Mol Biol2008, 17(2):125-135

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Weigert G., Kaya S., Pemp B., Sacu S., Lasta M., Werkmeister R.M., Dragostinoff N., Simader C., Garhofer G., Schmidt-Erfurth U., et al

What is interesting here is that transition to D-form results in exposure of a conserved cysteine residue which can be readily modified by thiol modifying reagents N-ethylmaleimide or iodoacetamide (Babot et al., 39 on Complex I subunit ND3, which forms part of the P-module, becomes exposed upon A to D transition and can then be modified by alkylating agents